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KMID : 1161520010050030231
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Animal Cells and Systems
2001 Volume.5 No. 3 p.231 ~ p.236
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Identification and phylogenetic analysis of sine-R Retroposon family in cDNA Library of human fetal brain
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Yi Joo-Mi
Shin Kyung-Mi
Lee Ji-Won
Paik In-Ho
Jang Kyung-Lib
Kim Heui-Soo
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Abstract
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SINE?R retroposons have been derived from human endogenous retrovirus HERV?K family and found to be hominoid specific. Both SINE?R retroposons and HERV?K family are potentially capable of affecting the expression of closely located genes. From cDNA library of human fetal brain, we identified seven SINE?R retroposons and compared them with sequences derived from GenBank database. The SINE?R retroposons from human fetal brain showed 85∼97% sequence similarities with the human?specific retroposon SINE?R.C2. They also showed 88∼96% sequence similarities with the sequence of the schizo?cDNA clone that derived from postmortem frontal cortex tissue of a schizophrenic patient. Phylogenetic analysis using the neighbor?joining method revealed that the seven new SINE?R retroposons from cDNA library of the human fetal brain have proliferated independently during human evolution. The data indicate that such SINE?R retroposons are expressed in human fetal brain and deserve further investigation as potential leads to understanding of neuropsychiatric diseases.
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KEYWORD
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cDNA library, HERV-K family, Human fetal brain, Neuropsychiatric diseases, Phylogeny, SINE-R retroposon
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